There are medicines that can help with some symptoms of IBS such as pain, constipation or diarrhoea. Medicines can help to control the severity of the symptoms but they don't reverse or cure the condition.
Each person with IBS will have different symptoms and medicines are aimed at easing your worst
Ask your doctor, nurse or a dietitian for dietary advice. Many people with IBS find that certain foods such as FODMAPS can trigger symptoms and following a low-FODMAP diet can be beneficial.
Abdominal pain and bloating medicines
Anti-spasmodics
Medicines that relax the stomach (tummy) muscles can be used to used to relieve tummy cramps or spasm-type pain that can occur with IBS. They can also help to ease bloating. These medicines are called anti-spasmodics.
Examples of anti-spasmodics include hyoscine tablets (Buscopan® or Buscopan Forte®) and mebeverine (Colofac®).
Your healthcare provider may recommend a 1 week trial of taking these regularly. If they work, then you may be advised to use them as required, when the symptoms arise. Read more about hyoscine tablets and mebeverine.
Peppermint oil
There is some evidence that peppermint oil may be useful for bloating, wind and bowel cramps. However, for some people, peppermint oil can cause or worsen reflux (indigestion).
In Aotearoa New Zealand, peppermint oil is available as capsules (Mintec® and Colpermin®).
Your healthcare provider may recommend a trial of 1 capsule taken 3 times daily 30 to 60 minutes before meals for 2 weeks. If it's helpful, you can continue taking these, but reduce the amount you're taking to the lowest effective dose. Ask your pharmacist for advice on how to take peppermint oil capsules.
Constipation medicines
If your main symptom is constipation, laxatives may help. There are a variety of different laxatives which work in different ways. Some laxatives can cause bloating, flatulence and discomfort, which can make your IBS worse. Your healthcare provider or pharmacist can advise on the best laxative for you. You may need to try a few laxatives before you find the right one. Read more about laxatives.
Diarrhoea medicines
If diarrhoea (runny poo) is your main problem, medicines such as loperamide may be helpful to increase stool firmness, decrease stool frequency and reduce urgency. This can be used in combination with an anti-spasmodic such as mebeverine.
Loperamide works by slowing the movement of your gut, and in this way reduces the number of bowel motions and firms up runny poos.
Your prescriber will start you on a low dose and, depending on your symptoms, may increase your dose gradually. Don't take more than 8 tablets in 24 hours.
An approach that has been suggested for people who are fearful of the sudden and urgent need to defaecate (poo) that can occur with IBS, is for them to take 2 to 4 mg of loperamide approximately 45 minutes before leaving their house. This is particularly helpful if access to a toilet is limited, such as when shopping or exercising.
Note: Additional doses need to be carefully managed to avoid constipation later in the day. Discuss the best options with your doctor or pharmacist.
Another medicine that may be used for diarrhoea associated with IBS is mebeverine. Read more about loperamide and mebeverine.
Other medicines
Antidepressants
Some people may be started on a trial of antidepressants such as amitriptyline or nortriptyline. These are used to relieve pain and slow the movement of your gut, rather than to treat psychological symptoms.
You'll be started on a low dose and, if needed, your dose will be increased but only after 3 to 4 weeks. Amitriptyline or nortriptyline may not be suitable if you also have constipation. Read more about amitriptyline and nortriptyline.
Probiotics
There is some evidence to support the use of probiotics for irritable bowel syndrome. A 4-week trial of probiotics in the form of yoghurts or other fermented milk products can be considered. However, some of these products also contain ingredients that may make IBS symptoms worse, such as fructans, fructose or lactose. If there's no improvement after 4 weeks, stop. A probiotic containing bifidobacterium infantis 35624 has the most evidence for its use. Read more about probiotics.