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Breztri Aerosphere

Key points about Breztri Aerosphere

Breztri Aerosphere is used to treat COPD.
Breztri Aerosphere contains 3 medicines (budesonide, glycopyrronium and formoterol) in a single inhaler.
Find out how to use Breztri Aerosphere correctly and possible side effects.

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Breztri Aerosphere® is used to treat moderate to severe chronic obstructive pulmonary disease (COPD). COPD is a group of diseases that affect your lungs and airways, causing breathing difficulties. Learn more about COPD and medicines for COPD.

Breztri Aerosphere contains 3 medicines (budesonide, glycopyrronium and formoterol) mixed in 1 inhaler.

Budesonide reduces swelling and irritation in the airways in your lungs. It belongs to a group of medicines known as inhaled corticosteroids.
Glycopyrronium and formoterol work together to relax the muscles in your airways. This helps to open your airways and makes it easier for air to flow in and out of your lungs.

The benefit of having 3 medicines in a single inhaler means you only need to use 1 inhaler instead of 2 or 3. You won't need to use other 'preventer' inhalers for your COPD.

Breztri Aerosphere comes as a metered dose inhaler (MDI) or puffer. This means when the inhaler is pressed, a measured dose of medicine comes through the mouthpiece.
To get the most benefit from your inhaler, it's important to use the correct technique. Ask your healthcare provider to show you how to use the inhaler. For guidance, read more below about how to use your Breztri Aerosphere inhaler.
Breztri Aerosphere is funded for people with moderate to severe COPD who are using 2 or 3 inhalers daily and meet other criteria. Talk to your healthcare provider to see if Breztri Aerosphere is suitable for you.

Breztri Aerosphere is a long-term treatment. It doesn't give immediate relief from sudden breathing problems such wheezing, a tight chest and shortness of breath

To treat these symptoms, use your ‘reliever’ medicine, eg, salbutamol (Respigen®, SalAir®, Ventolin®) or terbutaline (Bricanyl® Turbuhaler®).
Remember to continue using your Breztri Aerosphere inhaler each day.
To work well, Breztri Aerosphere must be used twice a day, every day.

The dose of Breztri Aerosphere is 2 puffs twice a day.
Shake your inhaler well before each puff.
Use your inhaler at the same time each day, in the morning or evening. This will give the right space between doses and help you to remember to use it.
If you miss a dose, you can take it as soon as you remember. But if it's nearly time for your next dose, just take your next dose at the right time. Don't take an extra dose to make up for a missed dose.
Since COPD is a long-term condition, the use of Breztri Aerosphere is ongoing. Keep using your inhaler every day. Don't stop using it, even if you feel better.
Follow your healthcare provider's instructions carefully. The pharmacy label on your medicine will tell you how much to use, how often to use it and any special instructions. Also see below: How to use your Breztri Aerosphere inhaler.

Use your inhaler with a spacer

A spacer is an attachment to use with your inhaler. It's a chamber that holds the medication before you inhale, giving you a more controlled, deeper inhalation. This can be especially helpful if you are short of breath.
Using your Breztri Aerosphere inhaler with a spacer makes it easier to use the inhaler and helps to get the medicine into your lungs, where it’s needed (with less medicine ending up in your mouth and throat).

Image credit: Healthify He Puna Waiora

Priming your inhaler

Before first use: Every time you get a new Breztri Aerosphere inhaler, you will need to prime the inhaler before you start using it. Priming is needed to make sure the inhaler fills with the right amount of medicine from the first time you use it.

Remove the mouthpiece.
Shake the inhaler well and spray 1 test-puff into the air facing away from you. Do this for a total of 4 test-puffs, shaking the inhaler before each test-puff.
It's important not to skip priming. Extra puffs are in the inhaler for priming.

Re-priming your inhaler: You will need to re-prime your inhaler:

after rinsing the yellow actuator (inhaler case) when cleaning your inhaler
if you accidentally drop your inhaler
if you haven't used your inhaler for more than 7 days.

To re-prime your inhaler you will need to spray 2 test puffs into the air facing away from you, shaking the inhaler before each test-puff.

Clean your inhaler ONCE a week

Your inhaler can get blocked if medicine builds up inside it, so try to clean it weekly.

Here are some things to know when you're using Breztri Aerosphere. Other things may be important as well, so ask your healthcare provider what you should know about.

Rinse your mouth with water after using your inhaler

Breztri Aerosphere contains budesonide, which can cause a sore throat, hoarse voice and thrush in your mouth.
Some of the medicine may stay behind in your mouth after each dose, so after each use, rinse your mouth with water and spit it out, so no medicine stays in your mouth. This reduces the chance of side effects.

Keep track of your doses so you don't run out

Breztri Aerosphere has a dose counter so you know exactly how many doses are left in the inhaler. Your inhaler has 120 doses.
The dose counter counts down by 1 each time you spray a puff of medicine. When the counter points to the yellow zone, contact your healthcare provider for a new inhaler.
Throw away your inhaler when the pointer is at 0 in the red zone. Don't try to take a puff of medicine when the pointer is at 0 because you won't get a full dose.

Discard your inhaler 3 months after first use

Breztri Aerosphere comes in a foil pouch. Once you have opened the package, the inhaler should be used within 3 months.
Write down the date you open it so you know.
Don’t open the pouch until you're ready to use your inhaler.

Check your inhaler technique regularly

It's very important to use your inhalers correctly, otherwise you may not be getting enough medicine into your lungs.
Ask your healthcare provider to watch you use your inhaler so you can be sure you're doing it properly.

If your inhaler doesn't seem to be working as well, check with your healthcare team

Some people have difficulty using this type of inhaler, because you need to coordinate breathing with inhaling the medicine.
It's important to use a spacer with these inhalers to make it easier to get the medicine into your lungs.
Your healthcare team will be able to check your technique and help you with this.

Like all medicines Breztri Aerosphere can cause side effects, although not everyone gets them. Often side effects improve as your body adjusts to the new medicine.

Side effects	What should I do?
Change in voice (hoarse voice) Different taste in your mouth Cough	After using your inhaler, rinse your mouth with water and spit it out, so no medicine stays in your mouth. Tell your healthcare provider if these bother you.
Signs of oral thrush (a fungal infection in your mouth) such as a sore tongue or mouth, with a white coating on your tongue or in your mouth. Read more about thrush.	Tell your healthcare provider.
Headache Pain in your arms and legs Stomach or back pain Muscle cramp and spasms Shaking (tremor) Constipation or diarrhoea Nervousness	Tell your healthcare provider if these bother you.
Blurred vision Dizziness	Tell your healthcare provider. Don't drive or use machinery. Don't drink alcohol.
Changes in your heartbeat (fast or irregular)	Tell your doctor immediately or ring Healthline on 0800 611 116.
Signs of infection such as cough, increase in mucus (sputum) production, change in mucus colour, fever and chills, difficulty breathing or worsening of your breathing problem.	Tell your doctor immediately or ring Healthline on 0800 611 116.