Dexamfetamine

This information is intended for use ONLY after you have been prescribed dexamfetamine.

Key points about dexamfetamine

  • Dexamfetamine is used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).
  • Find out how to take it safely and possible side effects.
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Dexamfetamine is used to treat narcolepsy, a sleep disorder that causes you to feel excessively tired during the daytime but have disturbed sleep during the night. Dexamfetamine works by stimulating the central nervous system to increase your alertness and reduce excessive sleepiness during the day.

Dexamfetamine is also used to treat attention deficit hyperactivity disorder (ADHD), for people who don't find methylphenidate helpful. Dexamfetamine helps with concentration, impulsion control, and calming. It's a stimulant that works by increasing the amount of dopamine, a chemical in your brain.

Funding of dexamfetamine

In Aotearoa New Zealand dexamfetamine is funded under a Special Authority, for people who meet the criteria. A special authority means your specialist will need to make an application to Pharmac (the government medicine funding agency) for approval before the medicine can be funded for you.

  • From December 2024 Pharmac has removed the special authority renewal requirements for dexamfetamine. This means that once special authority approval has been granted, it won't need to be renewed. Your doctor or nurse practitioner can continue to prescribe it.
  • Previously, people needed input from a specialist every 2 years to renew their special authority. 
  • Read more about the removal of the renewal criteria for stimulant treatments(external link).

In Aotearoa New Zealand dexamfetamine is available as tablets (5 mg). 

  • The dose of dexamfetamine will be different for different people, depending on your age and your response to the medication.
  • Your doctor will start you on a low dose and increase it gradually over a few weeks. This allows your body to get used to the medicine and reduces side effects. 
  • Always take dexamfetamine exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much dexamfetamine to take, how often to take it and any special instructions.

  • Timing: Dexamfetamine is usually taken 1 to 3 times a day. Take your first dose when you wake up in the morning. If more doses are prescribed, take them by early afternoon. Taking this medication late in the day may cause trouble sleeping (insomnia). 
  • Swallow your tablets with a glass of water: You can take dexamfetamine with or without food, as directed by your doctor.
  • Missed dose: If you forget to take your dose, take it as soon as you remember. But if it's nearly time for your next dose, just take the next dose at the right time. Don't take double the dose to make up for a forgotten dose. Avoid taking dexamfetamine in the late afternoon or evening because it can cause sleep problems.

Here are some things to know when you're taking dexamfetamine. Other things may be important as well, so ask your healthcare provider what you should know about.


Taking other medicines

Dexamfetamine interacts with some medications, herbal supplements and rongoā Māori, so check with your doctor or pharmacist before starting dexamfetamine and before starting any new products.


Limit or avoid drinking alcohol while you're taking dexamfetamine

Dexamfetamine and alcohol affect your heart and blood pressure, increasing your risk of side effects. Dexamfetamine is a stimulant that increases your body’s activity, while alcohol is a depressant and lowers your level of functioning. Since they have opposite effects, dexamfetamine can mask the effects of alcohol making it take longer to feel the effects of alcohol which can risk alcohol poisoning.


Be careful when driving or using tools until you know how this medicine affects you

Dexamfetamine may cause blurred vision, make you feel dizzy, or affect your focus – especially when you start taking it.

You may need to take dexamfetamine for several months or even years, but it's unlikely that you'll need to take it for the rest of your life.

  • Regular check-ups: You'll have regular check-ups, usually every 6 months or so, to see how well the medicine is working and if any changes are needed. Your healthcare provider will check your blood pressure, heart rate and weight.
  • Medicine holiday: Your doctor may recommend stopping dexamfetamine for a while, or reducing the dose. For children, this will normally be during the school holidays and can be called 'a medicine break'. This is to check whether it’s still helping.
  • Teenage reassessment: As your child gets to puberty, or just after, they will be assessed to see if the medicine is still needed. If the medicine is still helping, it may be recommended your child keeps taking it, even as an adult.
  • Don't stop dexamfetamine suddenly: Talk to your doctor first, as it might be best to reduce the dose gradually. This reduces the risk of having side effects when you stop taking this medicine.

Like all medicines, dexamfetamine can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Side effects What should I do?
  • Difficulty falling asleep 
  • Take your first dose when you wake up in the morning. 
  • If you're taking more than 1 dose per day, take the second or third dose by midday or early afternoon.
  • Dizziness
  • Problems with your vision


  • Don't drive or operate machinery.
  • Don't drink alcohol
  • Anxiety
  • Nervousness
  • irritability 
  • Changes in mood
  • Feelings of harming yourself or others
  • Tell your doctor or ring Healthline 0800 611 116.
  • Headache
  • Lower appetite
  • Dry mouth
  • Stomach (tummy) pain
  • Constipation or diarrhoea (runny poo) 
  • Tell your doctor if they bother you.
  • Chest pain
  • Fainting
  • Fast or irregular heartbeat 
  • Tell your doctor immediately or ring Healthline 0800 611 116.

 

Read more about medicines and side effects and reporting a reaction you think might be a side effect.

Brochures

Medicines and side effects
Healthify He Puna Waiora, NZ, 2024

5 questions to ask about your medications

5 questions to ask about your medications

Health Quality and Safety Commission, NZ, 2019 English, te reo Māori

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Credits: Healthify editorial team. Healthify is brought to you by Health Navigator Charitable Trust.

Reviewed by: Angela Lambie, Pharmacist, Auckland

Last reviewed: