Rosuvastatin

Sounds like 'ro-su-va-stat-in'

Key points about rosuvastatin

Rosuvastatin is used to lower raised cholesterol and reduce your chance of heart disease and stroke.
Rosuvastatin is also called Crestor.
It belongs to a group of medicines known as statins.
Find out how to take it safely and possible side effects.

Rosuvastatin is a medicine that reduces the amount of cholesterol made by your body by blocking the action of a certain enzyme that's needed to make cholesterol. It belongs to a group of medicines known as statins.

If you have high cholesterol

Rosuvastatin is used to lower raised cholesterol. Having high cholesterol increases your risk of cardiovascular disease and having a heart attack or stroke. Read more about high cholesterol.

Cholesterol is a type of lipid made by your liver and from the fatty foods that you eat. Everyone has cholesterol and triglycerides in their blood. They are needed by your body for many things such as hormone production and brain function.
Your body needs some cholesterol but if the amount in your blood gets too high, it can cause small fatty patches called plaques (or atheroma) to form.
Over time, these patches can build up and make your blood vessels narrow and stiff (a process called atherosclerosis). The narrowing reduces the blood flow through your arteries and can cause heart attack, angina and stroke.
Rosuvastatin helps to reduce atherosclerosis and reduces your risk of having a heart attack or stroke.

If you have normal cholesterol but are at risk of heart disease and stroke

Rosuvastatin can also reduce your chance of heart disease and stroke if you have an increased risk of it, even if your cholesterol levels are normal.

When deciding whether you should take a statin or not, your healthcare provider will look at your overall risk of having a heart attack or stroke in the future.
They use calculations to work out your individual risk, including information about your age, sex, ethnicity, blood pressure, whether you smoke and if you have diabetes. Read more about heart risk assessment.
If your overall risk of having a heart attack or stroke is high, even if your cholesterol level is normal, a statin may be recommended. This is because even if the amount of cholesterol in your blood is normal, there may already be fatty plaques in your arteries which increases your risk of cardiovascular disease.

Note: Taking a statin, such as rosuvastatin is just one way to reduce your risk of cardiovascular disease. Making lifestyle changes including eating a healthy diet, staying active, staying at a healthy weight, drinking less alcohol, and not smoking can also reduce your risk of cardiovascular disease.

After a heart attack or stroke

Rosuvastatin is used after a heart attack or stroke to lower your risk of having another heart attack or stroke. When they're started soon after a heart attack, statins also reduce the lipid content of fatty plaques and stabilise them. This also help reduce your chance of having another heart attack.

Funding of rosuvastatin

In Aotearoa New Zealand rosuvastatin is funded under a Special Authority, for people who meet the criteria. A special authority means your healthcare provider will need to make an application to Pharmac (the government medicine funding agency) for approval before the medicine can be funded for you.

Rosuvastatin tablets are available in different strengths: 5 mg, 10 mg, 20 mg and 40 mg. Your dose of rosuvastatin will depend on why you're taking it, your cholesterol levels, and other medicines you may be taking.

For high cholesterol: The usual starting dose is 10 mg once a day. Some people may start on a lower dose (5 mg once daily). Your healthcare provider may increase your dose every few weeks up to 20 mg a day.
To prevent heart attacks and strokes: The usual dose is 20 mg once a day, although sometimes a lower dose is prescribed. If you have very high cholesterol and are at high risk of heart attacks or strokes, a specialist may prescribe 40 mg a day. This dose is not suitable for everyone.
Always take rosuvastatin exactly as your healthcare provider has told you.
The pharmacy label on your medicine will tell you how much rosuvastatin to take, how often to take it and any special instructions.

Differences between people

Some people are more likely to get side effects and require lower doses of rosuvastatin, due to their genetics (how their bodies are made up). Genetic makeup can vary by ethnicity. For example people of Asian origin (including Filipino, Chinese, Japanese, Korean, Vietnamese, and people from the Indian subcontinent) need lower doses of rosuvastatin than Caucasian patients. Read more about how your genes (DNA) affect the way you respond to some medicines (pharmacogenomics).

Timing: Take rosuvastatin once a day, at about the same time each day. Swallow each tablet whole with a drink of water.
Food: You can take rosuvastatin with or without food.
Missed dose: If you forget your dose, take it as soon as you remember that day. But if it's nearly time for your next dose, just take the next dose at the usual time. Don't take double the dose.

Here are some things to know when you're taking rosuvastatin. Other things may be important as well, so ask your healthcare provider what you should know about.

Alcohol: Avoid drinking large amounts of alcohol while you're taking rosuvastatin. Heavy drinking can increase your risk of side effects such as problems with your liver.
Monitoring: You may need to see your healthcare provider regularly when you first start taking rosuvastatin to make sure the dose is right for you. High cholesterol doesn’t have any symptoms so you won’t notice any changes after taking rosuvastatin. That's why it’s important to have a blood test to check the changes in your cholesterol levels.
Keep taking rosuvastatin regularly: To reduce your cholesterol effectively, you must keep taking rosuvastatin every day. Treatment with rosuvastatin is usually long term.
Get the full benefit: To get the full benefit of a statin, it's important to eat a healthy diet, exercise regularly and limit your alcohol intake. It's best to eat a low-fat diet, and reduce the amount of saturated fat you eat. Read more about fats.
Other medicines: Rosuvastatin interacts with some medicines, herbal supplements and rongoā Māori, so check with your healthcare provider or pharmacist before starting rosuvastatin or before starting any new medicines or supplements.
Pregnancy or breastfeeding: Talk to your healthcare provider if you're pregnant, planning a pregnancy or want to breastfeed.

Like all medicines, rosuvastatin can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Muscle pain or weakness

You may get muscle pain or weakness when taking statins. This is rarely serious and often goes away with time. If your pain comes on shortly after you start your statin, or gets worse, see your healthcare provider. They will check an enzyme called creatine kinase to see if the aches and pains are possibly being caused or made worse by the statins. If so:

a lower dose or a different statin may be prescribed
you may choose to continue living with the aches because of the benefits of the statin
you may discuss stopping taking your statin with your prescriber.

They will also want to check for a rare but serious condition called rhabdomyolisis, as well as check any other medicines you are taking. Rhabdomyolisis can be caused by an interaction between statins and some other medicines.

Other side effects

Side effects	What should I do?
Diarrhoea (runny poo) Stomach upset Bloating or gas in your tummy Nausea (feeling sick) Sleep problems Headache, dizziness, tiredness	These are quite common when you first start taking rosuvastatin, and usually go away with time. Tell your healthcare provider if they bother you.
Muscle aches and pains or muscle weakness	Tell your healthcare provider.
Signs of problems with your liver such as dark-coloured pee, yellowing of your skin or eyes, or a sharp pain in your stomach area	Tell your healthcare provider immediately or phone Healthline 0800 611 116.
Signs of an allergic reaction such as itchy skin and rash, swelling of lips or tongue	Tell your healthcare provider immediately or phone Healthline 0800 611 116.