Proton pump inhibitors

Also called PPIs

Key points about proton pump inhibitors

  • Proton pump inhibitors are also called PPI's.
  • PPIs reduce the amount of acid made by your stomach.
  • PPIs are used together with antibiotics to get rid of the bacteria.
  • Find out about PPIs and possible side effects.
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Examples of PPIs available in New Zealand include:

Omeprazole, pantoprazole and lansoprazole are available on prescription at a subsidised cost. Omeprazole can be bought in limited quantities without prescription from your pharmacy. 

PPIs reduce the amount of acid made by your stomach. They are used to treat some conditions associated with high stomach acid affecting your stomach and gut, such as:

  • gastro-oesophageal reflux disease (GORD), which is inflammation of the lining of your oesophagus (gut) due to stomach acid leaking up (refluxing) from your stomach
  • peptic ulcers, which are small holes in the lining of your stomach (called stomach ulcers) or another part of your gut called the duodenum (called duodenal ulcers).

They are also used:

  • to prevent ulcers in people who are at risk of getting them, such as people who take NSAIDs (non-steroidal anti-inflammatory drugs) long-term and those who are in hospital
  • together with antibiotics to get rid of the bacteria called Helicobacter pylori, found in your stomach, which can cause ulcers
  • to treat a rare condition called Zollinger-Ellison syndrome.

PPIs work by reducing the amount of acid that your stomach produces. They still allow enough acid to be made to digest your food, but by reducing the amount, they allow the lining of your stomach and oesophagus to heal. Most stomach ulcers are caused by a bacteria called Helicobacter pylori, which makes your stomach lining red and inflamed, and more likely to have ulcers. PPIs are used together with antibiotics to get rid of the bacteria. PPIs are also prescribed for patients with GORD because, by reducing the amount of acid produced by your stomach, they reduce the burning of your oesophagus.

PPIs are generally safe and well tolerated. However, to reduce the risk of side effects, it is important that you are on the lowest dose possible, for the shortest time possible. Depending on your condition, your doctor may prescribe a PPI that you only take as required to relieve your symptoms, rather than every day. In some cases, a regular dose taken each day is necessary.

Avoid long-term use – choose wisely

If you don’t need them, PPIs should not be taken long term, because of the possible side effects. There may be a small increased risk of bone fractures, chest infections, kidney problems, gastric cancer and nutrient deficiencies such as low magnesium and vitamin B12. If you’ve been taking a PPI for GORD for longer than 4 to 8 weeks, and your symptoms seem to be well managed, it’s a good idea to talk to your health care provider about reviewing your medicine. They may recommend stepping down your treatment. This could include:

  • reducing your daily dose of medicine
  • taking your medicine only when you experience the symptoms of heartburn and reflux (also known as on-demand therapy)
  • stopping treatment completely as your symptoms may not return. It may be best to reduce the dose over a few weeks before stopping.

Read more about PPIs for heartburn and reflux(external link) Choosing Wisely, NZ 

Rebound acid secretion

When PPIs are stopped, a common side effect is rebound acid secretion, where the acid secretion in your stomach increases significantly. This should return to normal within 2 weeks. Because the symptoms of rebound acid secretion are the same as for GORD (such as indigestion, discomfort and pain in your upper stomach and chest, feeling sick and an acid taste in your mouth), it can form an ongoing loop where stopping PPI treatment creates the need to start it again.

Rather than restart PPIs, your doctor may advise you to use medicines that contain both an antacid and an anti-foaming agent, such as Acidex oral liquid or Gaviscon Double Strength tablets. Alternatively, ranitidine tablets can be used. These can be effective for treating rebound acid secretion. You can use these medicines to relieve the symptoms when they occur.

Talk to your doctor or pharmacist about how to manage rebound acid secretion.

The following links provide further information about PPIs. Be aware that websites from other countries may have information that differs from New Zealand recommendations.

Proton Pump Inhibitors(external link) Patient Info, UK


  1. Proton pump inhibitors: When is enough, enough?(external link) BPAC, June 2014
  2. Proton pump inhibitors and the risk of acute kidney injury.(external link) BPAC, July 2016
  3. Hypomagnesaemia with proton pump inhibitors(external link) BPAC, April 2013
  4. Hypomagnesaemia - a risk associated with all proton pump inhibitors(external link) Medsafe Prescriber Update, December 2012, 33(4): 32
  5. Small risk of gastric cancer with long term use of PPI(external link) Goodfellow Gems, NZ, 2022 


 Heartburn and reflux
Choosing Wisely

5 questions to ask about your medications
5 questions to ask about your medications

Health Quality and Safety Commission, NZ, 2019

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Credits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust.

Reviewed by: Angela Lambie, Pharmacist, Auckland

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