Paracetamol

This is the most commonly available strength as tablets or caplets. They are immediate-release tablets, meaning that they start to work straight away. 

• Dose: The usual dose in adults is 1 or 2 tablets every 4 to 6 hours when required for pain. Do not take more than 4 doses in 24 hours ( 8 tablets in 24 hours). Exceeding the recommended dose can be harmful to your liver.
• Timing: Depending on the reason you are taking paracetamol, your doctor may advise that you take regular doses or take it only when you need it for pain relief. Wait at least 4 hours between doses. Keep track of the timing of your doses and check when it was last taken before taking it again.

The 665 mg tablets are used for osteoarthritis. These are modified-release tablets, where the dose is delivered over a longer time period. This means you can take fewer doses throughout the day.

• Swallow the tablets whole. Do not crush or chew them.
• Dose: The usual dose in adults is 2 tablets every 6 to 8 hours when required for pain. Do not take more than 6 tablets in 24 hours. Exceeding the recommended dose can be harmful to your liver.
• Timing: Depending on the reason you are taking paracetamol, your doctor may advise that you take regular doses or take it only when you need it for pain relief. Wait at least 6 hours between doses. Keep track of the timing of your doses and check when it was last taken before taking it again.

Some people may need lower doses of paracetamol

Some people should take less than the usual dose, for example if you have liver problems, weigh less than 50 kg, consume excessive amounts of alcohol or if you are dehydrated. Taking the usual dose may be harmful to your liver. Speak to your pharmacist or doctor if you are not sure what dose to take.

Taking paracetamol with other pain medicines

Paracetamol is found in many pain medicines you can buy from the pharmacy such as Maxigesic and Nuromol. An overdose can happen if you take more than 1 paracetamol-containing medicine.

If you do take other medicines that have paracetamol in them, be careful not to take more than the recommended dose of paracetamol each day (4 grams in 24 hours). If you are taking paracetamol 665 mg modified release tablets, do not take other products containing paracetamol.

It's safe to take paracetamol with other types of pain medicines that don't contain paracetamol, such as ibuprofen, and opioid medicines such as codeine. They all work differently so the type of medicine you need to treat your pain depends on what type of pain you have.

Paracetamol is found in many cold and flu products

Check the ingredients of cold and flu medicines before you take them. Paracetamol is found in many cold and flu products, eg, Codral®, Coldrex® and Lemsip®. If you do take other medicines that have paracetamol in them, be careful not to take more than the recommended dose of paracetamol each day (4 grams in 24 hours). If you are taking paracetamol 665 mg modified release tablets, do not take other products containing paracetamol. Check with your pharmacist if you are not sure whether a product contains paracetamol.

Paracetamol is a very popular medicine and when taken correctly works well. However, too much paracetamol is very harmful to your liver.

If you realise you have had too much paracetamol (including from other products with paracetamol in them), call your doctor, nurse or the Poisons Centre  0800 POISON (0800 764 766) immediately.

Do NOT wait for signs of an overdose as these appear late when the damage to your liver is already done.

Late signs may include:

• nausea (feeling sick) or vomiting (being sick)
• diarrhoea (runny poo)
• yellow skin or eyes
• poor appetite
• confusion or extreme sleepiness.

Older people are most at risk, so should take extra care.