Pancreatic enzyme supplements

In Aotearoa New Zealand, the funded brand of pancreatic enzyme supplements is Creon®, which comes in different strengths (Creon 10000, Creon 25000 and Creon Micro). Each strength contains a different mix of the enzymes lipase, protease and amylase.

• The dose varies depending on your condition and the type of meal you're having.
• You will need to take more enzymes for larger meals or for meals containing more fat, as these need more enzymes to digest them.
• It's important not to change what you eat to try to manage your symptoms as you may not get all the nutrients you need. Rather, make sure you take enough enzymes for what you're eating.
• Your doctor or dietitian will advise you on the best dose for you and give you guidance on how to adjust your dose.

Note: You don't need pancreatic enzyme supplements if you're eating food/drinks that have no protein or fat. For example fresh, dried or canned fruit by itself (except for avocados), jelly, sorbet, soft drinks, juice, cordial, clear soup, clear broth, hard boiled lollies, sweets, tea or coffee with a dash of milk and sugar. These foods are easily digested and absorbed and you don’t need to have pancreatic enzymes with them.

Timing of your dose

• Take your dose with every meal or snack that has fat and protein in it. You should also take it with drinks that are more than half milk.
• Usually, you should take the capsules with your first bite of food. If you're taking more than 1 capsule, you may find it better to take half the dose when you start eating and then spread the remaining throughout the meal to make sure the enzymes are properly mixed with food in your gut.
• Don't take the enzymes at the end of the meal as they won't be as effective.

Note: You don’t need to take pancreatic enzyme supplements if you're not eating or drinking. They only work when taken with food. You also don't need them if you're eating food or drinks that have no protein or fat. For example fresh, dried or canned fruit, jelly, sorbet, soft drinks, juice, cordial, clear soup, clear broth, tea or coffee with a dash of milk and sugar. These foods are easily digested and absorbed and you don’t need to have pancreatic enzymes with them.

Swallow capsules whole

• Take the capsules with a few sips of a water or a cool drink. The enzymes won’t work properly if you take them with hot drinks.
• Don't crush or chew the capsules as this can give you a sore mouth.
• If they're hard to swallow, you can open the capsule, mix the contents in a small amount of room-temperature acidic food (eg, yoghurt, apple sauce, bananas, tomato sauce) and eat your food straight away. Make sure to take some sips of fluids to clear your mouth after so there aren’t any beads stuck in your mouth.
• You shouldn't sprinkle the contents of the capsules on a plate of food, as they won’t work this way.

Missed doses

• Don’t worry if you forget to take your dose. Just take the usual dose with your next meal or snack. You may have some symptoms for the next day or two, but this will improve.
• Missing a few doses doesn’t cause any long-term problem, but over time if you miss more doses you will have problems putting on weight or will start to lose weight.

Here are some things to know when you're taking pancreatic enzyme supplements. Other things may be important as well, so ask your healthcare provider what you should know about.

How do I know if my dose is right for me?

You should see a change in how your poo (bowel motion) looks.

• It should be more formed, less pale, and should flush away easily.
• You shouldn't have pain when you're eating and should have less wind (gas).
• You may start to gain weight, especially if you've been losing weight unintentionally.
• Important: Don't stop taking the capsules without speaking to your doctor. Your doctor or dietitian can help you adjust your dose.

Taking other medicines

Pancreatic enzyme supplements can interact with some medicines, herbal supplements and rongoā Māori. Please check with your doctor or pharmacist before starting pancreatic enzyme supplements and before starting any new products.

Take care when storing the capsules

• Store the capsules in a cool dry place between 15 and 25°C. T
• Avoid keeping the capsules in hot places (eg, direct sunlight, a car glove box or trouser pocket) or the fridge as this will affect the enzymes.
• Always keep the lid sealed on the bottle of capsules.
• Check the expiry date of capsules and don't use them past this date. After opening the container, use the capsules within 6 months.
• Dispose of capsules that have changed colour or texture.

Like all medicines, pancreatic enzyme supplements can cause side effects, although not everyone gets them.