Progestogen-only oral contraceptive pill

Also called the 'mini-pill’.

Key points about the progestogen-only contraceptive pill

  • The progestogen-only contraceptive pill (POP) is a form of contraception to prevent pregnancy. 
  • The POP is sometimes known as 'the mini pill'.
  • It contains only progestogen.
  • Examples include Microlut®, Noriday® and Cerazette®.
  • Find out how to take it safely and possible side effects.
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The progestogen-only contraceptive pill (POP) is a form of contraception to prevent pregnancy. It contains only progestogen, a hormone similar to that produced by your ovaries. It doesn't contain oestrogen. For oestrogen-containing contraception, see the combined pill.

There are 3 brands of POPs available in Aotearoa New Zealand – Cerazette, Microlut and Noriday. Each has different progestogens, which affect how they work. In each box, there are 3 cards of 28 hormone pills. There are no ‘sugar’ pills.

 


Cerazette

Cerazette has the progestogen desogestrel.

  • It works mainly by preventing ovulation (stops your ovaries releasing an egg). This makes it more effective at preventing pregnancy compared with other POPs. It also causes changes to the lining of your womb (uterus) so there’s less chance a fertilised egg will attach to it.
  • You must take your tablet within 12 hours of the same time each day.

Note: Cerazette is also used to help manage the symptoms of endometriosis and there is some evidence that it may be used as menopausal hormone therapy (MHT). These are currently unapproved uses in Aotearoa New Zealand. Read more about Cerazette


Microlut and Noriday

Microlut has the progestogen levonorgestrel and Noriday has the progestogen norethisterone.

  • Microlut and Noriday work mainly by thickening the mucus in your cervix so sperm can’t travel through it. They don't stop you ovulating.
  • You must take your tablet within 3 hours of the same time each day.

Your prescriber will discuss the best pill for you. If you experience side effects, or if you keep forgetting to take your pill, you may need to try another brand or another type of contraception before you find one that suits you.

Pros

Cons

✔ It doesn’t interfere with sex.

✔ It can be used when you're breastfeeding.

✔ There are very few side effects.

 

✘ It must be taken each day at the same time of the day whether you have sex on that day or not.

✘ It doesn't protect against sexually transmitted infections (STIs), so it’s important to use condoms when you have sex.

✘ It may cause irregular bleeding for a few months after starting. As long as you haven't missed any pills, it will still be working as a contraceptive. If the bleeding continues, talk to your healthcare provider.

The POP is one of the more reliable forms of contraception.

  • It's usually 92% effective, which means that it prevents pregnancy in 92 out of 100 women who use the POP each year.
  • If used perfectly (no pills are missed), the POP is more than 99% effective in preventing pregnancy.
  • To ensure that the POP works best, you need to remember to take it every day, at about the same time every day, whether you have sex on that day or not.

The POP may not work properly if you miss a pill, are vomiting (being sick) or have ongoing diarrhoea (runny poo). This can stop the pill from being absorbed properly. Read more about what to do if you miss a dose and what to do if you have vomiting or diarrhoea.

Some medicines or herbal remedies may also stop the pill from working. Ask your prescriber or pharmacist about how any other medicines you need to take might affect it. 

You must take the POP every day with no breaks. There are no inactive (sugar) pills.

  • The usual dose of the POP is 1 tablet once a day. 
    • Most brands of the POP must be taken within 3 hours of the same time each day.
    • Cerazette® must be taken within 12 hours of the same time every day.
  • You can take the POP with or without food.
  • You can start taking the POP at any time in your menstrual cycle if you are certain you're not pregnant.
    • If you start on the first day of your period it starts working immediately. 
    • If you start at any other time during your menstrual cycle, it will take 48 hours to start working. This means, to be safe, you need to use additional contraception (eg, condoms) or not have sex for 48 hours (2 days) after starting.
  • If you want to start the POP but think you may be pregnant, take a pregnancy test 21 days after the last time you had unprotected sex before you start taking the POP.

The advice for a missed pill depends on which brand you're taking.


Microlut and Noriday

A dose is considered 'missed' when more than 3 hours have passed since the regular dosing time.

  • If you forget to take the pill on time, take it as soon as you remember and take the next pill at the normal time (even if this means you take 2 pills within the same day). 
  • If you are more than 3 hours late in taking it then your protection immediately fails. Take your pill as soon as you remember, and continue taking your pill each day. However, you will also need to use extra contraception (eg, condoms), or avoid sex for the next 48 hours, until you have taken three consecutive pills. The POP will be effective again.    
  • If you have unprotected sex within 48 hours of restarting the progestogen-only pill, contact your doctor, nurse, pharmacist or call Healthline 0800 611 116 for advice. You may need to use emergency contraception.


Cerazette

If you're taking Cerazette, a 'missed' dose is when more than 12 hours have passed since the regular dosing time.

  • If you forget to take your pill on time, take it as soon as you remember and take the next pill at the normal time (even if this means you take 2 pills within the same day). 
  • If you are more than 12 hours late in taking it then your protection immediately fails. Take your pill as soon as you remember and continue taking your pill each day. However, you will also need to use extra contraception (such as condoms), or avoid sex for the next 48 hours, until you have taken three consecutive pills. Cerazette will be effective again.
  • If you have unprotected sex within 48 hours of restarting Cerazette, contact your doctor, nurse, pharmacist or call Healthline 0800 611 116 for advice. You may need to use emergency contraception. 

If you're not sure about what to do if you have missed 1 or more pills, contact your doctor, nurse, pharmacist or call Healthline 0800 611 116 for advice.

Vomiting (being sick) and ongoing diarrhoea (runny poo) from illness or laxatives can interfere with the effectiveness of the POP. The advice on what to do depends on the brand you're taking.


Microlut and Noriday

  • If you vomit within 2 hours of taking your pill, take another pill as soon as possible.
  • If you don't take a replacement pill within 3 hours of the usual time, or if you have ongoing diarrhoea lasting more than 24 hours, use condoms or avoid having sex, until you have been taking the pill correctly for 48 hours (you have taken three consecutive pills).  
  • If you've had unprotected sex while you were unwell or within 48 hours of restarting the POP contact your doctor, nurse, pharmacist or call Healthline 0800 611 116 for advice. You may need to use emergency contraception.


Cerazette

  • If you vomit within 2 hours of taking your pill, take another pill as soon as possible.
  • If you don't take a replacement pill within 12 hours of the usual time, or if you have ongoing diarrhoea lasting more than 24 hours, use condoms or avoid having sex, until you have been taking the pill correctly for 48 hours (you have taken three consecutive pills).
  • If you've had unprotected sex while you were unwell or within 48 hours of restarting Cerazette, contact your doctor, nurse, pharmacist or call Healthline 0800 611 116 for advice. You may need to use emergency contraception. 

If you're not sure about what to do if you have diarrhoea and vomiting, contact your doctor, nurse, pharmacist or call Healthline 0800 611 116 for advice.

It's safe to take the POP when you're breastfeeding

POPs don't affect breastmilk production. If you've just had a baby, you can start taking it straight away. If you start it more than 3 weeks after having a baby, you need to use additional contraception (eg, condoms) or not have sex for 48 hours (2 days) after starting.



The POP may be an option when you can't use the combined pill for medical reasons, eg, having a history of:

  • blood clots or at risk of having blood clots
  • migraines
  • heavy smoking
  • very high blood pressure or heart disease
  • diabetes with complications
  • not being able to tolerate oestrogen.


The POP must be used with caution if you:

  • have ischaemic heart disease or stroke or a past history of these conditions
  • have trouble remembering to take your pill each day.


The POP is NOT recommended if you have:

  • unexplained vaginal bleeding
  • severe liver problems, eg, cirrhosis or liver tumours
  • breast cancer, or have recently had breast cancer.

Cerazette, Microlut or Noriday can be purchased from some pharmacies without a prescription if you meet the criteria. Your pharmacist will ask questions about your health and other medicines you're taking. There will be a charge for the medication and appointment.


When can the pill be purchased without a prescription?

You can get the pill from your pharmacy if you have had a prescription within the last 3 years and you are 1 of the following:

  • from Aotearoa New Zealand and have run out of your contraception pill
  • from overseas and have run out of your contraception pill
  • collecting the emergency contraceptive pill and have used the contraceptive pill before
  • wanting to restart the contraceptive pill and have used it before
  • wanting the contraceptive pill after having a baby and have used it before.

If you are breastfeeding you can be given a progesterone-only pill. For other situations, the pharmacy will refer you back to your healthcare provider.

If you are unsure whether you are eligible for over the counter contraceptive, talk to the pharmacist.


Who can't purchase the pill without a prescription from their pharmacy?

There are some cases where the pill can't be purchased without a prescription from your pharmacy. This includes:

  • If you're under the age of 16 years.
  • You haven't had a prescription for this pill within the last 3 years.
  • If you have risk factors that need medical supervision.

Like all medicines, the POP can cause side effects, although these are very rare and not everyone gets them.  As with all progestogen-only pills, the most common side effect is irregular bleeding. This is a nuisance but it's not dangerous. Often side effects improve as your body gets used to the new medicine.

Side effects What should I do?
  • You may have irregular bleeding or spotting
  • Your period may be less regular or may stop, which is preferred by some people
  • Continue to take your pill everyday. You shouldn't stop it if you get some bleeding or spotting. If you stop and start the pill often, it may cause irregular bleeding and it won’t work as a contraceptive.
  • It can often take a few months for bleeding to settle down, so it’s worth continuing for 3 months at least.
  • Tell your prescriber if this bothers you or doesn't go away.
  • Breast discomfort
  • Feeling sick (nausea) 
  • Headaches
  • Mood changes
  • Skin changes such as acne
  • These are very uncommon and often go away with time.
  • If they're severe and ongoing, or if you're vomiting or have ongoing diarrhoea, tell your doctor or nurse.


Read more about medicines and side effects and reporting a reaction you think might be a side effect.

The following links provide further information about the POP:

Progestogen-only oral contraceptive pill(external link) Sexual Wellbeing Aotearoa, NZ
Progesterone-only contraceptive pill(external link) Health New Zealand | Te Whatu Ora, NZ
 
More detailed information on specific brands of the POP:
Cerazette(external link) Medafe, NZ
Microlut(external link) Medafe, NZ
Noriday(external link) Medafe, NZ


References

  1. Progestogen-only oral contraceptives(external link) New Zealand Formulary
  2. NZ Aotearoa’s guidance on contraception(external link) Ministry of Health, NZ, 2020

Brochures

Medicines and side effects
Healthify He Puna Waiora, NZ, 2024

5 questions to ask about your medications

5 questions to ask about your medications

Health Quality and Safety Commission, NZ, 2019 English, te reo Māori

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Credits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust.

Reviewed by: Angela Lambie, Pharmacist, Auckland

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