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Quetiapine

Sounds like 'kweh-tie-ah-peen'

Key points about quetiapine

Quetiapine is used to treat bipolar disorder and schizophrenia.
Quetiapine is also called Quetapel® or Seroquel®.
Find out how to take it safely and possible side effects.

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Quetiapine is used to treat schizophrenia and bipolar disorder. Quetiapine doesn't cure these conditions, but is used to help ease the symptoms and help you on your recovery path.

It can help symptoms such as mania of bipolar disorder, the experience of hearing voices (hallucinations), ideas that distress you and don't seem to be based in reality (delusions), and difficulty in thinking clearly (thought disorder). It can also help with the depressive episodes associated with bipolar disorder.
Quetiapine belongs to a group of medicines called antipsychotics. Read more about antipsychotic medicines and how they work.

April 2025 update: Quetiapine 25mg tablets (Quetapel brand) supply issue. The latest shipment of 25 mg tablets has been delayed. From 1st of April an alternative Quetapel 25 mg tablet is available. It's made by the same company as your usual quetiapine. The tablets and the packaging look different. The packaging is designed for people in Japan. Read more about the Quetiapine (Quetapel) 25 mg tablet: Supply issue(external link) and the brochure about the changes(external link).

In Aotearoa New Zealand quetiapine is available as tablets (25 mg, 100 mg, 200 mg, 300 mg).

The dose of quetiapine is different for different people.
Your doctor will start you on a low dose and increase it over a few days. This allows your body to get used to the medicine and reduces side effects
Always take your quetiapine exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much quetiapine to take, how often to take it, and any special instructions.

Quetiapine is usually taken twice a day, for mania or schizophrenia, in the morning and evening. Take your quetiapine doses at the same times each day. If you are taking quetiapine for depression associated with bipolar disorder, take it once a day, at bedtime.
You can take quetiapine with or without food. Don't take it with large quantities of grapefruit juice as it changes the levels of quetiapine causing side effects. Read more about grapefruit and medicines.
If you forget to take your dose, take it as soon as you remember that day. But if it is nearly time for your next dose, just take the next dose at the right time. Don't take double the dose.
Keep taking quetiapine every day. It usually takes a few weeks to start working and it can take several months before you feel the full benefits. Don't stop taking quetiapine suddenly as your symptoms may return if stopped too early. Talk to your doctor or nurse before stopping.

Here are some things to know when you're taking quetiapine. Other things may be important as well, so ask your healthcare provider what you should know about.

Alcohol: Avoid alcohol while you are taking quetiapine, especially when you first start treatment. Alcohol can increase your risk of side effects such as dizziness and drowsiness.
Driving: Quetiapine can make you sleepy and dizzy so be careful when driving or using tools until you know how it affects you.
Other medicines: Quetiapine can interact with other medicines. Tell your doctor or pharmacist about all medicines you are taking including over the counter medicines, herbal and complementary medicines or recreational drugs.
Quetiapine may cause changes in your blood glucose level, cholesterol level and heart function. Your doctor will check your physical health – you may need to have your weight and blood pressure (BP) measured regularly. You may also need blood tests to check your kidneys, liver, and cholesterol and glucose levels.
Quetiapine is best avoided for people with certain medical conditions such as Parkinson’s disease, epilepsy and depression that is not associated with bipolar disorder and diabetes. Contact your doctor if you have or develop any of these conditions while taking it.
Contact your doctor if you're pregnant or planning a pregnancy or if you are breastfeeding.
Quetiapine can make your skin more sensitive to sunlight. Protect yourself, even on a bright but cloudy day; use sunscreen and wear a hat. Don't use sunbeds.

Like all medicines, quetiapine can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Side effects	What should I do?
Feeling sleepy, drowsy or tired Dizziness	This is quite common especially when you first start taking quetiapine. Don’t drive or operate machinery until you know how this medicine affects you. Avoid drinking alcohol – it makes the drowsiness and dizziness worse. These effects puts you at increased risk of falls, especially if you are elderly. Tell your doctor if these bother you.
Increased appetite Weight gain	This is common when taking quetiapine. Eat a diet full of vegetables and fibre and limit sugary or fatty foods. Exercise regularly. Talk to your doctor if you are concerned. Read more about medicines and weight gain.
Sexual problems such as low libido and erectile dysfunction	Talk to your doctor if this is a problem
Worsening depression or thoughts of self-harm	Tell your doctor immediately or phone Healthline on 0800 611 116.
Constipation	Ask your doctor to prescribe a suitable laxative, which you need to take on a regular basis. Eat more fruit, vegetables, brown bread, bran-based breakfast cereals and drink plenty of water. Read more about medicines and constipation.
Signs of problems with your liver, such as sudden pains in your stomach, loss of appetite or yellowing of your skin and eyes	Tell your doctor immediately or phone Healthline on 0800 611 116.

Bipolar disorder | Mate rangirua
Schizophrenia | Mate wairua tuakoi
Antipsychotic medicines

The following links have more information on quetiapine. Be aware that websites from other countries may contain information that differs from Aotearoa New Zealand recommendations.

Med-ucation medication benefits & side effects(external link) Talking Minds, NZ
Quetapel(external link) Medsafe Consumer Information, NZ
Seroquel(external link) Medsafe Consumer Information, NZ
Quetiapine(external link) Patient Info, UK