Nortriptyline to quit smoking
Sounds like nor-TRIP-ti-LEAN
Key points about nortriptyline for quitting smoking
- Nortriptyline is used to help adults stop smoking.
- Nortriptyline is also called Norpress®.
- Find out how to take it safely and possible side effects.

Nortriptyline is used to help adults stop smoking. It is usually used when nicotine replacement therapy (NRT) has not been effective. It can help to reduce negative nicotine withdrawal symptoms such as anxiety and stress. Nortriptyline is available on prescription from your doctor.
Note: Nortriptyline is also used to treat depression and nerve pain (neuropathic pain). This page focuses on its use for quitting smoking only.
Taking nortriptyline increases your chances of quitting smoking. It approximately doubles the chances of giving up smoking long-term. It doesn't contain nicotine, which is important to some people.
- In Aotearoa New Zealand nortriptyline is available as tablets (10 mg and 25 mg).
- The effect of nortriptyline is not immediate. It's best to start nortriptyline 10 to 28 days before you plan to stop smoking. This allows it to build up in your body before you stop smoking completely.
- Take 25 mg once a day before your target stop date. Your doctor will increase this slowly over a 10 day to 5 week period.
- The usual maximum dose is 75 to 100 mg daily.
- The usual duration of treatment is 12 weeks. However, your doctor may tell you to take nortriptyline for up to 6 months.
- Swallow the tablets whole with a glass of water.
- You can take nortriptyline with or without food.
- If you forget to take your dose, skip the dose you missed and take the next dose when you are meant to. Don't take double the dose.
- Continue taking nortriptyline until your doctor tells you to stop. Your doctor will reduce your dose slowly to avoid any withdrawal symptoms.
Here are some things to know when you're taking nortriptyline. Other things may be important as well, so ask your healthcare provider what you should know about.
- Nortriptyline may affect your ability to drive: Nortriptyline can affect your concentration (how you focus or pay attention). It can slow your reaction times and cause sleepiness, blurred vision, dizziness, or make you feel anxious or jittery. Be careful when driving or using tools until you know how this medicine affects you. Don't drive if you experience any of these. If you are a driver, talk to your doctor if you're worried.
- Let your doctor or pharmacist know about any other medicines you are taking, including over-the-counter medicines, vitamins or herbal supplements.
Like all medicines, nortriptyline can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.
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Read more about medicines and side effects and reporting a reaction you think might be a side effect. |
Norpress(external link) Medsafe Consumer Information Sheet, NZ
Resources
5 questions to ask about your medications(external link) Health Quality and Safety Commission, NZ, 2019 English(external link), te reo Māori(external link)
References
- Update on smoking cessation(external link) BPAC, NZ 2010
- Nortriptyline(external link) NZ Formulary, NZ 2022
Brochures
Medicines and side effects
Healthify He Puna Waiora, NZ, 2024
Health Quality and Safety Commission, NZ, 2019 English, te reo Māori
Credits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust.
Reviewed by: Angela Lambie, Pharmacist, Auckland
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