Leflunomide

In Aotearoa New Zealand leflunomide is available as tablets (10 mg and 20 mg).

• The dose of leflunomide is different for different people, depending on your condition and response to treatment.
• Always take leflunomide exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it and any special instructions.

• Try to take your dose at the same time each day. You can take leflunomide with or without food.
• Swallow your tablets whole with a drink of water. Do not break, chew or crush the tablets.
• If you forget to take your leflunomide dose, take it as soon as you remember. But if it is nearly time for your next dose, take the next dose at the right time. Do not take double the dose.
• Keep taking leflunomide regularly. Leflunomide does not work straight away. It usually takes a few weeks or months before you notice the full benefits.

Here are some things to know when you're taking leflunomide. Other things may be important as well, so ask your healthcare provider what you should know about.

• Avoid or limit alcohol while you are taking leflunomide. Alcohol increases your risk of side effects such as liver problems. 
• You will need to have regular blood tests to monitor for side effects and to check whether the treatment is effective. Blood tests are very important during the first few months of treatment.
• Leflunomide weakens your body’s defence (immune) system, so you are more likely to get infections. It's important to avoid anyone who has chickenpox or shingles.
• It's important to avoid becoming pregnant while you are taking leflunomide and for some time after you have stopped taking it. Talk to your healthcare provider about which types of contraception are suitable for you. Let your doctor know if you are thinking about becoming pregnant.
• Some vaccines should not be taken if you are on leflunomide. Always check with your doctor or pharmacist first. It is safe for you to have the annual flu vaccine.
• Leflunomide may interact with some other medicines and herbal supplements, so check with your doctor or pharmacist before starting leflunomide or before starting any new medicines, including those you may buy over the counter.

Like all medicines, leflunomide can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.