Ankylosing spondylitis

Also known as AS

Key points about ankylosing spondylitis

  • Ankylosing spondylitis (AS) is a form of inflammatory arthritis involving your spine.
  • Pain and stiffness in your back and neck are common symptoms.
  • Men are affected by AS more often than women.
  • AS can be hereditary.
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Ankylosing spondylitis (AS) causes ongoing inflammation of soft tissues around the spinal bones (vertebrae). Over time, this inflammation may cause bones in the pelvis and sometimes parts of the spine to fuse together. 

This fusing can cause loss of movement of the spine and occasionally can result in a hunched-over posture. In a small number of people, the condition is severe enough for them to stop work or change their employment.

ankylosing spondylitis graphic showing joint inflammation

Image credit: 123rf

The name Ankylosing spondylitis comes from a combination of Greek words: ankylos meaning fused; spondylos meaning vertebrae; and itis meaning inflammation.

A team of health professionals, including your GP, rheumatologist and physiotherapist, may be involved in your care.

Video: Ankylosing Spondylitis Symptoms

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(Arthritis NZ, 2011)

There is a strong tendency for AS to run in families, especially if you have a close relative with AS. About half this risk is related to a single gene called HLA-B27. Other risk factors for AS include the following:

  • Crohn’s disease: there is a genetic overlap between AS and inflammation of the bowel.
  • Being between the ages of 15 and 35: symptoms usually develop within this age range; it is rare for people older than 40 years to develop it.
  • Being male: men are generally more severely affected than women; the reasons for this are unknown.
  • Smoking: tends to make AS worse; stopping smoking may be helpful.

The most common symptoms are pain and stiffness in the buttocks, back and neck – often causing people to wake up at night. The stiffness tends to improve once people get moving.

Symptoms include:

  • Pain in the buttocks  can be on one side only.
  • Pain in the back or neck – may have a gradual onset but doesn’t go away.
  • Stiffness or pain in the morning that improves once you start moving.
  • Feeling better after exercise; worse after rest,
  • Sleeplessness – especially in the second half of the night.
  • Sometimes joints such as knee and tendons, especially around the ankle, can also be inflammed.
  • Some people can get inflammation in the eye, causing a red, painful eye.

If these symptoms last for more than three months see your GP to get them checked. If it is ankylosing spondylitis, getting a management plan can help.

Early diagnosis of ankylosing spondylitis is important because impact and potential for loss of mobility can be reduced with correct management. Although there is currently no cure or prevention for AS, the treatment options have widened in recent years so the disease can be well managed.

If you have symptoms of AS, your GP will refer you to a rheumatologist. The diagnosis of AS is made from:

  • an assessment of your symptoms
  • a physical examination
  • blood tests
  • x-rays or MRI scans.

Your rheumatologist will explain the result of each test.

Treatment of AS is provided by a team of health professionals such as your GP, rheumatologist, physiotherapist, occupational therapist and orthotist or podiatrist when required. Treatment usually involves medication to reduce inflammation, together with lifestyle measures.

Video: Managing Your Ankylosing Spondylitis

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(National Axial Spondyloarthritis Society, UK, 2017)


Medicines will decrease inflammation and prevent joint damage. They fall into the following categories.

Medication Description
(non steroidal anti-inflammatory drugs)
  • Examples include ibuprofendiclofenac and naproxen.
  • These are usually the first medicines prescribed in the treatment of AS. NSAIDs can lessen pain and stiffness by reducing inflammation.
  • For most people, taking NSAIDs is safe. However, extra care is needed if you have stomach ulcers or kidney problems. Read more about NSAIDs.
Pain relievers
  • Pain relievers such as paracetamol can help to ease the pain; sometimes used together with other medicines.


(also called steroids)

  • These are used to reduce the pain and inflammation usually while waiting for other medication to take effect. They may also be used to treat sudden flare-ups but are not usually needed after the flare-up has settled.
  • Steroids may be given as tablets, such as prednisone, or as injections directly into the joint itself or into the muscle or vein.
Biologic medicines ('biologics')
  • These are the latest disease-modifying medicines used for treating severe AS and can be very effective in those severely affected. They are given by injection.
  • The biologics that can be used for AS include adalimumab, etanercept and infliximab. The are also called TNF inhibitors.

Lifestyle measures are also helpful in AS. 

Maintaining good posture

Try to maintain an upright posture when standing and sitting. People with AS have a tendency to bend forwards and stoop and this may impact negatively on the spine’s function.

  • When standing, keep your body weight balanced and even on both feet with shoulders relaxed, back and down.
  • Keep the back of the neck long, allowing the chin to drop slightly forwards.
  • Do not stand still for too long and when moving, try to maintain this tall, relaxed posture.

Specially designed chairs and supportive cushions are available to help maintain correct posture while driving or sitting at a desk and simple devices are available to make gardening easier.

Keep moving

Make a habit of being physically active. Performing exercises that are designed to stretch tight muscles and ligaments encourages full mobility and strengthens postural muscles.

  • Do exercises designed to increase the strength and endurance of postural muscles, to make it easier to keep in an upright position.
  • Specific AS exercises for up to 30 minutes a day, at least 5 times a week (preferably every day), are recommended.
  • A moderate, consistent exercise programme is generally the best way to get results for AS.
  • Read more about exercise and ankylosing spondylitis(external link)(external link).

Plan your activities

Preserve energy by planning or pacing your daily activities. Feeling tired is common for people with AS. Plan and pace your daily activities and vary your tasks so that you allow time to rest and relax. 

Try relaxation

Practicing relaxation is important especially if your rib joints are involved. Learning how to relax your muscles and getting rid of tension can help to decrease pain, improve sleep and energy levels.

Quit smoking

Stop smoking because smoking is associated with worse pain and problems with mobility in AS. Read more about smoking and AS(external link)(external link).

Get a good night’s sleep

Having a good night’s sleep is essential for rest and repair of the body.

  • Use a mattress that gives support.
  • Sleep in a position that is most comfortable, but if on the side, avoid a lot of bending at the hips and knees.
  • A few simple stretching exercises in the evening before going to bed may improve your sleep.

Eat a balanced diet

Although there is no scientific evidence that diet has an effect on AS, a balanced diet helps maintain general health and energy levels. Read more about healthy eating

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Credits: Healthify editorial team. Healthify is brought to you by Health Navigator Charitable Trust.

Reviewed by: Assoc Professor Rebecca Grainger, Rheumatologist, University of Otago and Hutt Valley DHB

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